Merz B, Bigalke H, Stoll G, Naumann M
Dept. of Neurology, University of Würzburg, Würzburg, Germany.
Clin Auton Res. 2003 Oct;13(5):337-8. doi: 10.1007/s10286-003-0118-2.
Botulism nowadays is a rare mostly food-borne disease caused by the toxin of Clostridium botulinum. On the other hand, botulinum toxin blocking cholinergic transmission has become a most powerful treatment option for many focal movement disorders and is increasingly used to treat autonomic disorders [2, 7, 8]. Although muscle weakness is the hallmark of botulism, autonomic dysfunction may be the leading clinical symptom in rare cases and should be included in the differential diagnosis of pure dysautonomia. Here, we describe a patient with autonomic dysfunction as the leading symptom of botulism type B.
如今，肉毒中毒是一种罕见的、主要由肉毒杆菌毒素引起的食源性疾病。另一方面，阻断胆碱能传递的肉毒杆菌毒素已成为许多局灶性运动障碍最有效的治疗选择，并越来越多地用于治疗自主神经功能障碍[2,7,8]。虽然肌肉无力是肉毒中毒的标志，但在罕见情况下，自主神经功能障碍可能是主要临床症状，应纳入单纯自主神经功能障碍的鉴别诊断。在此，我们描述了一例以自主神经功能障碍为主要症状的B型肉毒中毒患者。
