血小板计数与非肥胖型日本2型糖尿病患者的胰岛素抵抗独立相关。

Platelet count is independently associated with insulin resistance in non-obese Japanese type 2 diabetic patients.

作者信息

Taniguchi Ataru, Fukushima Mitsuo, Seino Yutaka, Sakai Masahiko, Yoshii Satoru, Nagasaka Shoichiro, Yamauchi Ichizoh, Okumura Takahide, Nin Kazuko, Tokuyama Kunpei, Yamadori Noriko, Ogura Masahito, Kuroe Akira, Nakai Yoshikatsu

机构信息

Division of Diabetes, Kansai-Denryoku Hospital, Osaka, Japan.

出版信息

Metabolism. 2003 Oct;52(10):1246-9. doi: 10.1016/s0026-0495(03)00099-4.

DOI:10.1016/s0026-0495(03)00099-4

PMID:14564674

Abstract

The aim of the present study was to investigate the relationship between platelet count and insulin resistance in non-obese Japanese type 2 diabetic patients. A total of 163 non-obese Japanese type 2 diabetic patients (112 men and 51 women, aged 36 to 84 years, body mass index [BMI] 16.2 to 26.9 kg/m(2)) were studied. In conjunction with BMI, glycosylated hemoglobin (HbA(1c)), fasting concentrations of plasma glucose and serum lipids (triglycerides, low-density lipoprotein [LDL] cholesterol, high-density lipoprotein [HDL] cholesterol, and total cholesterol), and hematological parameters (platelets, white blood cell count, red blood cell count, hematocrit, hemoglobin) were measured. LDL cholesterol was calculated using the Friedewald formula. Insulin resistance was estimated by the insulin resistance index of homeostasis model assessment (HOMA-IR). Univariate regression analysis showed that HOMA-IR was positively correlated to BMI (r = 0.465, P <.0001), HbA(1c) (r = 0.423, P <.0001), platelet count (r = 0.310, P <.0001), triglycerides (r = 0.277, P <.0005), white blood cell count (r =.222, P =.005), red blood cell count (r = 0.210, P =.008), hematocrit (r = 0.156, P =.047), total cholesterol (r = 0.178, P =.023), and systolic (r = 0.216, P =.011) and diastolic (r = 0.263, P =.002) blood pressure, and inversely correlated to HDL cholesterol (r = -0.312, P <.0001) level in our diabetic patients. Multiple regression analysis showed that HOMA-IR was independently predicted by BMI (P <.0001, F = 22.45), HbA(1c) (P <.0001, F = 16.15), platelet count (P <.0001, F = 10.75), and serum triglycerides (P <.0001, F = 10.47) levels, which explained 34% of the variability of HOMA-IR in non-obese Japanese type 2 diabetic patients. These results indicate that not only BMI, HbA(1c), and triglycerides levels but also platelet counts are independent predictor of insulin resistance in non-obese Japanese type 2 diabetic patients.

摘要

本研究的目的是调查非肥胖型日本2型糖尿病患者血小板计数与胰岛素抵抗之间的关系。共研究了163例非肥胖型日本2型糖尿病患者（112名男性和51名女性，年龄36至84岁，体重指数[BMI]为16.2至26.9kg/m²）。同时测量了BMI、糖化血红蛋白（HbA1c）、空腹血糖和血脂水平（甘油三酯、低密度脂蛋白[LDL]胆固醇、高密度脂蛋白[HDL]胆固醇和总胆固醇）以及血液学参数（血小板、白细胞计数、红细胞计数、血细胞比容、血红蛋白）。LDL胆固醇使用Friedewald公式计算。采用稳态模型评估胰岛素抵抗指数（HOMA-IR）评估胰岛素抵抗。单因素回归分析显示，在我们的糖尿病患者中，HOMA-IR与BMI（r = 0.465，P <.0001）、HbA1c（r = 0.423，P <.0001）、血小板计数（r = 0.310，P <.0001）、甘油三酯（r = 0.277，P <.0005）、白细胞计数（r =.222，P =.005）、红细胞计数（r = 0.210，P =.008）、血细胞比容（r = 0.156，P =.047）、总胆固醇（r = 0.178，P =.023）以及收缩压（r = 0.216，P =.011）和舒张压（r = 0.263，P =.002）呈正相关，与HDL胆固醇水平（r = -0.312，P <.0001）呈负相关。多因素回归分析显示，HOMA-IR由BMI（P <.0001，F = 22.45）、HbA1c（P <.0001，F = 16.15）、血小板计数（P <.0001，F = 10.75）和血清甘油三酯水平（P <.0001，F = 10.47）独立预测，这解释了非肥胖型日本2型糖尿病患者中HOMA-IR变异性的34%。这些结果表明，在非肥胖型日本2型糖尿病患者中，不仅BMI、HbA1c和甘油三酯水平，而且血小板计数都是胰岛素抵抗的独立预测因素。