Yoon Hee-Young, Kim Han-Na, Lee Su Hwan, Kim Soo Jung, Chang Yoosoo, Ryu Seungho, Shin Hocheol, Kim Hyung-Lae, Lee Jin Hwa
Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul 07804, Korea.
Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul 03181, Korea.
J Clin Med. 2019 Feb 10;8(2):230. doi: 10.3390/jcm8020230.
Platelet count reflects the severity and prognosis of multiple diseases. Additionally, alterations in gut microbiota have been linked to several chronic diseases. The purpose of this study was to investigate the association between gut microbiota and platelet count. We selected 1268 subjects with fecal 16S RNA gene sequencing data from a Healthcare Screening Center cohort. Based on the third quartile of platelets (277 × 10⁸/L), we compared the gut microbiota between the upper quartile ( = 321) and lower three quartiles groups ( = 947). The upper quartile group had lower alpha diversity based on observed amplicon sequence variants ( = 0.004) and phylogenetic index ( < 0.001) than the lower three quartiles group. Significant differences were also found in the weighted UniFrac distance ( = 0.001) and Jaccard dissimilarity ( = 0.047) beta diversity measures between the two groups. Compared with the lower three quartiles group, the upper quartile group exhibited decreased relative abundances of the genus , which was also inversely correlated with the platelet count. Increased platelet count was associated with reduced diversity in gut microbiota and lower abundances of with beneficial gut bacteria spices , suggesting that an increased platelet count, even within normal range, may adversely affect gut microbial diversity and composition.
血小板计数反映多种疾病的严重程度和预后。此外，肠道微生物群的改变与多种慢性疾病有关。本研究的目的是调查肠道微生物群与血小板计数之间的关联。我们从一个医疗筛查中心队列中选取了1268名有粪便16S RNA基因测序数据的受试者。基于血小板的第三个四分位数（277×10⁸/L），我们比较了上四分位数组（n = 321）和下三个四分位数组（n = 947）之间的肠道微生物群。与下三个四分位数组相比，上四分位数组基于观察到的扩增子序列变体（P = 0.004）和系统发育指数（P < 0.001）的α多样性较低。两组之间在加权UniFrac距离（P = 0.001）和Jaccard差异（P = 0.047）β多样性测量中也发现了显著差异。与下三个四分位数组相比，上四分位数组的属相对丰度降低，这也与血小板计数呈负相关。血小板计数增加与肠道微生物群多样性降低以及有益肠道细菌种类的相对丰度降低有关，这表明即使在正常范围内，血小板计数增加也可能对肠道微生物多样性和组成产生不利影响。
