2'-脱氧-2'-C-三氟甲基-β-D-核糖核苷类似物：合成与抗病毒评估。
2'-Deoxy-2'-C-trifluoromethyl beta-D-ribonucleoside analogues: synthesis and antiviral evaluations.
作者信息
Jeannot Frédéric, Gosselin Gilles, Mathé Christophe
机构信息
Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR 5625 CNRS, Université Montpellier II, Montpellier, France.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):857-9. doi: 10.1081/NCN-120022671.
PMID:14565296
Abstract
Hitherto unknown 2'-deoxy-2'-C-trifluoromethyl-beta-D-ribonucleoside derivatives bearing the five naturally occurring nucleic acid bases have been synthesized. The compounds were tested for their activity against HIV, HBV and several RNA viruses, but they did not show significant antiviral effect.
摘要
现已合成了带有五种天然存在核酸碱基的前所未知的2'-脱氧-2'-C-三氟甲基-β-D-核糖核苷衍生物。对这些化合物进行了抗HIV、HBV和几种RNA病毒活性的测试，但它们并未显示出显著的抗病毒效果。
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