1'-C-支链N,O-核苷的非对映选择性和对映选择性合成。
Diastereo- and enantioselective synthesis of 1'-C-branched N,O-nucleosides.
作者信息
Saita M G, Chiacchio U, Iannazzo D, Corsaro A, Merino P, Piperno A, Previtera T, Rescifina A, Romeo G, Romeo R
机构信息
Dipartimento Scienze Chimiche, Università di Catania, Catania, Italy.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):739-42. doi: 10.1081/NCN-120022623.
PMID:14565267
Abstract
A synthetic approach towards 1'-C-branched N,O-nucleosides is reported, based on 1,3-dipolar cycloaddition of ethoxycarbonylnitrone. The asymmetric version of the process exploits the presence of a chiral auxiliary at the carbon atom of nitrone and leads to beta-D and beta-L nucleosides in good yields.
摘要
报道了一种基于乙氧羰基硝酮的1,3-偶极环加成反应合成1'-C-支链N,O-核苷的方法。该反应的不对称版本利用了硝酮碳原子上手性助剂的存在，能以良好的产率得到β-D和β-L核苷。
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