Coutouli-Argyropoulou Evdoxia, Xatzis Christos, Argyropoulos Nikolaos G
Department of Chemistry, Laboratory of Organic Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Nucleosides Nucleotides Nucleic Acids. 2008 Jan;27(1):84-100. doi: 10.1080/15257770701572055.
New bicyclic isoxazolidine nucleoside analogues are synthesized through 1,3-dipolar cycloaddition of enantiopure cyclic nitrones to appropriate vinyl nucleobases. The reactions are diastereoselective, giving as the main or the sole product the exo-Re cycloadducts. The diastereoselectivity depends on both the kind of the base and the substitution pattern of the nitrone.
新型双环异恶唑烷核苷类似物通过对映体纯的环状硝酮与合适的乙烯基核碱基进行1,3-偶极环加成反应合成。这些反应具有非对映选择性，主要或唯一产物为外型-反式环加成物。非对映选择性取决于碱基的种类和硝酮的取代模式。
