Jeannot Frédéric, Gosselin Gilles, Mathé Christophe
Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR 5625 CNRS-Université Montpellier II, Montpellier, France.
Nucleosides Nucleotides Nucleic Acids. 2003 Dec;22(12):2195-202. doi: 10.1081/ncn-120026874.
3'-C-Trifloromethyl-beta-D-ribonucleoside derivatives bearing the five naturally occurring nucleic acid bases have been synthesized. All these derivatives were prepared by glycosylation reactions of purine and pyrimidine bases with a suitable peracylated 3-C-trifluoromethyl ribofuranose precursor. After deprotection, the resulting title nucleoside analogues were tested for their inhibitory properties against the replication of HIV, HBV and several RNA viruses. However, none of these compounds showed significant antiviral activity.
已合成了带有五种天然存在核酸碱基的3'-C-三氟甲基-β-D-核糖核苷衍生物。所有这些衍生物都是通过嘌呤和嘧啶碱基与合适的全酰化3-C-三氟甲基呋喃核糖前体进行糖基化反应制备的。脱保护后，对所得的标题核苷类似物进行了针对HIV、HBV和几种RNA病毒复制的抑制特性测试。然而，这些化合物均未显示出显著的抗病毒活性。
