5-炔基-和6-烷基呋喃并及吡咯并[2,3-d]嘧啶核糖核苷的2'-C-甲基类似物的合成与抗病毒评价
Synthesis and antiviral evaluation of 2'-C-methyl analogues of 5-alkynyl- and 6-alkylfurano- and pyrrolo[2,3-d]pyrimidine ribonucleosides.
作者信息
Januszczyk Piotr, Fogt Joanna, Boryski Jerzy, Izawa Kunisuke, Onishi Tomoyuki, Neyts Johan, De Clercq Erik
机构信息
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2009 May;28(5):713-23. doi: 10.1080/15257770903128870.
PMID:20183611
Abstract
A series of novel 2'-C-methylribonucleosides, involving 5-iodo and 5-alkynyl uridine analogues as well as related bicyclic furano- and pyrrolo[2,3-d]pyrimidinone compounds, has been synthesized and evaluated for their inhibitory effect on replication of the hepatitis C virus (HCV). The new nucleoside analogues did not show meaningful anti-HCV activity.
摘要
已合成了一系列新型的2'-C-甲基核糖核苷，包括5-碘代和5-炔基尿苷类似物以及相关的双环呋喃并和吡咯并[2,3-d]嘧啶酮化合物，并对它们抑制丙型肝炎病毒（HCV）复制的作用进行了评估。这些新的核苷类似物未显示出有意义的抗HCV活性。
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