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脱氮和脱氧腺苷衍生物：作为人类感染模型的动物病毒的合成与抑制

Deaza- and deoxyadenosine derivatives: synthesis and inhibition of animal viruses as human infection models.

作者信息

Vittori Sauro, Salvatori Daniela, Volpini Rosaria, Vincenzetti Silvia, Vita Alberto, Taffi Sara, Costanzi Stefano, Lambertucci Catia, Cristalli Gloria

机构信息

Dipartimento di Scienze Chimiche, Università di Camerino, Camerino, Italy.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):877-81. doi: 10.1081/NCN-120022676.

DOI:10.1081/NCN-120022676
PMID:14565301
Abstract

N6-Cycloalkyl-2',3'-dideoxyadenosine derivatives and (2-chloro)-N6-cycloheptyl-3-deazaadenosine have been synthesized and tested, along with other (deaza)purine (deoxy)nucleosides from our chemical library, as inhibitors of virus replication against Bovine Herpes Virus 1 (BHV-1) and sheep Maedi/Visna Virus (MVV). Most compounds demonstrated good antireplicative activity against MVV, showing also low cell toxicity.

摘要

已合成并测试了N6-环烷基-2',3'-二脱氧腺苷衍生物和(2-氯)-N6-环庚基-3-脱氮腺苷，以及我们化学文库中的其他(脱氮)嘌呤(脱氧)核苷，作为抗牛疱疹病毒1型(BHV-1)和绵羊梅迪/维斯纳病毒(MVV)复制的抑制剂。大多数化合物对MVV表现出良好的抗复制活性，且细胞毒性也较低。

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