Thormar H, Balzarini J, Debyser Z, Witvrouw M, Desmyter J, De Clercq E
Institute of Biology, University of Iceland, Reykjavík.
Antiviral Res. 1995 May;27(1-2):49-57. doi: 10.1016/0166-3542(94)00082-j.
Several anti-HIV agents were tested against visna virus replication and cytopathic effect (CPE) in sheep choroid plexus cell cultures. Sulphated polysaccharides (i.e., dextran sulphate, pentosan polysulphate and heparin) and plant lectins, which inhibit viral adsorption and fusion, were found to be 10- to 40-fold less active against visna virus than against HIV. Bicyclam derivatives were at least 250-fold less active against visna virus and the highly HIV-1 specific TIBO derivatives were without a significant inhibitory effect on visna virus at subtoxic concentrations. In contrast, several 2',3'-dideoxynucleosides and acyclic nucleoside phosphonate analogues, which inhibit reverse transcription, were found to be very effective inhibitors of visna virus replication and viral CPE in cell culture.
在绵羊脉络丛细胞培养物中测试了几种抗HIV药物对维斯纳病毒复制和细胞病变效应（CPE）的作用。发现抑制病毒吸附和融合的硫酸化多糖（即硫酸葡聚糖、戊聚糖多硫酸盐和肝素）以及植物凝集素对维斯纳病毒的活性比对HIV的活性低10至40倍。双环胺衍生物对维斯纳病毒的活性至少低250倍，而高度HIV-1特异性的替博韦衍生物在亚毒性浓度下对维斯纳病毒没有显著抑制作用。相比之下，发现几种抑制逆转录的2'，3'-双脱氧核苷和无环核苷膦酸类似物是细胞培养中维斯纳病毒复制和病毒CPE的非常有效的抑制剂。
