尿中修饰核苷作为肿瘤标志物。
Urinary modified nucleosides as tumor markers.
作者信息
Dudley E, Lemiere F, Van Dongen W, Esmans E, El-Sharkawi A M M, Games D E, Brenton A G, Newton R P
机构信息
Biochemistry Group, School of Biological Sciences, University of Wales Swansea, Singleton Park, Swansea, UK.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):987-9. doi: 10.1081/NCN-120022719.
Extracts of urinary nucleosides have been sequentially purified and examined by mass spectrometric analysis. Seventeen modified nucleosides have been unequivocally identified and a further five provisionally identified. While several nucleosides were found only in a small number of extracts, the occurrence and levels of others were found to correlate with the tumour type and stage.
尿核苷提取物已被依次纯化，并通过质谱分析进行检测。已明确鉴定出17种修饰核苷，另有5种为初步鉴定。虽然仅在少数提取物中发现了几种核苷，但发现其他核苷的出现情况和水平与肿瘤类型及分期相关。
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