含3'-脱氧-3'-C-亚甲基尿苷的寡脱氧核苷酸的合成及杂交特性
Synthesis and hybridization properties of oligodeoxynucleotides containing 3'-deoxy-3'-C-methyleneuridine.
作者信息
Lindegaard Dorthe, Wengel Jesper
机构信息
Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Odense M, Denmark.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1159-61. doi: 10.1081/NCN-120022825.
PMID:14565369
Abstract
3'-Deoxy-3'-C-methyleneuridine nucleoside 1 has been incorporated into oligodeoxynucleotides. Relative to the unmodified references, oligomers containing nucleoside 1 displayed reduced binding affinities towards complementary DNA and RNA with a tendency towards RNA-selective hybridization.
摘要
3'-脱氧-3'-C-亚甲基尿苷核苷1已被掺入到寡脱氧核苷酸中。相对于未修饰的参比物，含有核苷1的寡聚物对互补DNA和RNA的结合亲和力降低，具有RNA选择性杂交的倾向。
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