Synthesis and properties of oligodeoxyribonucleotides bearing a polyamino group at the 2' position via 2'-O-carbamoylmethyl and 2'-S-carbamoylmethyl groups.
作者信息
Ozaki Hiroaki, Nomura Shingo, Momiyama Shingo, Yokotsuka Kazuyuki, Kuwahara Masayasu, Sawai Hiroaki
机构信息
Department of Chemistry and Chemical Biology, Graduate School of Engineering, Gunma University, Kiryu, Gunma, Japan.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2009 Oct;28(10):943-52. doi: 10.1080/15257770903307185.
PMID:20183563
Abstract
An oligodeoxyribonucleotide containing 2 '-O-methoxycarbonylmethyluridine was synthesized and converted into several 2 '-modified oligodeoxyribonucleotides by a postsynthetic modification method. Using this method, oligodeoxyribonucleotides bearing a polyamine at the 2 ' position were easily prepared, which could form duplexes with either complementary DNA or RNA.
摘要
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