Synthesis of a cyclopentane amide DNA analogue and its base pairing properties.
作者信息
Ahn Dae-Ro, Mosimann Markus, Leumann Christian J
机构信息
Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1207-10. doi: 10.1081/NCN-120022837.
PMID:14565381
Abstract
cpa-DNA monomers containing the bases adenine and thymine have been synthesized starting from the known compound 1 in 12 steps. Partially and fully modified cpa-thymidine and cpa-adenosine containing oligodeoxynucleotides were synthesized by standard oligonucleotide chemistry. Fully modified homo-cpa-A sequences lead to duplex destabilization by -1.4 degrees C/mod. relative to DNA. As its congener bca-DNA, cpa-DNA prefers left-handed duplex formation where possible.
摘要
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