与DNA结合的含吡咯聚酰胺核苷的合成与分析
Synthesis and analysis of nucleosides bearing pyrrolepolyamide binding to DNA.
作者信息
Kawashima Etsuko, Itoh Daisuke, Kamaike Kazuo, Terui Yusuke, Oshima Tairo
机构信息
Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo, Japan.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1309-11. doi: 10.1081/NCN-120022953.
PMID:14565406
Abstract
An efficient synthesis of adenosine bearing pyrrolepolyamide 1 was achieved by coupling of 3 with 2. The CD spectra obtained at several [ligand ]/[duplex] ratios allowed verification of the formation complex of the DNA duplex [d(CGCAAATTGGC)/d(GCCAATTTGCG)] with 1.
摘要
通过3与2的偶联实现了含吡咯聚酰胺1的腺苷的高效合成。在几个[配体]/[双链体]比例下获得的圆二色光谱允许验证DNA双链体[d(CGCAAATTGGC)/d(GCCAATTTGCG)]与1形成的复合物。
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