Morgan Susan J, Prince H Miles, Westerman David A, McCormack Christopher, Glaspole Ian
Department of Haematology, Peter MacCallum Cancer Institute, East Melbourne, Vic., Australia.
Leuk Lymphoma. 2003 Sep;44(9):1623-5. doi: 10.3109/10428190309178789.
A patient with marked chronic eosinophilia and episodic angioedema (Gleich's syndrome) with a concomitant clonal proliferation of helper T-lymphocytes is described. This association has not previously been documented. The symptoms and clinical course differ markedly from the idiopathic hypereosinophilic syndrome, including an absence of end organ involvement. However, the disease appears to have a similar pathogenesis, with elevated levels of the eosinophil-specific cytokine interleukin-5 (IL-5) produced by the T-cell clone.
本文描述了一名患有显著慢性嗜酸性粒细胞增多症和发作性血管性水肿（格莱希综合征）的患者，其伴有辅助性T淋巴细胞的克隆性增殖。此前尚未有这种关联的记录。该病症的症状和临床病程与特发性嗜酸性粒细胞增多综合征明显不同，包括无终末器官受累。然而，该疾病似乎具有相似的发病机制，即T细胞克隆产生的嗜酸性粒细胞特异性细胞因子白细胞介素-5（IL-5）水平升高。
