Murakami T, Kato J, Kogawa K, Watanabe N, Sakamaki S, Kohgo Y, Hamabe K, Ishiyama N, Enokihara H, Niitsu Y
Department of Internal Medicine (Section 4), Sapporo Medical College, Japan.
Intern Med. 1993 Apr;32(4):343-5. doi: 10.2169/internalmedicine.32.343.
A case of episodic angioedema and eosinophilia syndrome is reported. An 18-year-old male suffered from monthly episodes of angioedema, pruritic papules, weight gain, and fever for twelve years. During the episodes, peripheral eosinophils and serum levels of interleukin (IL)-5, an eosinophil proliferating cytokine were elevated. Extensive evaluations disclosed neither visceral involvement nor evidence of parasitic infections, collagen diseases, or neoplastic disorders. Corticosteroid treatment brought about a dramatic clinical improvement concomitant with decrement of eosinophils and serum IL-5 was observed. These observations suggest that IL-5 may be a causative factor for this pathological state.
报告了一例发作性血管性水肿和嗜酸性粒细胞增多综合征病例。一名18岁男性，12年来每月发作血管性水肿、瘙痒性丘疹、体重增加和发热。发作期间，外周嗜酸性粒细胞以及嗜酸性粒细胞增殖细胞因子白细胞介素（IL）-5的血清水平升高。广泛评估未发现内脏受累，也未发现寄生虫感染、胶原病或肿瘤性疾病的证据。皮质类固醇治疗带来了显著的临床改善，同时观察到嗜酸性粒细胞减少以及血清IL-5下降。这些观察结果表明，IL-5可能是这种病理状态的致病因素。
