Schiavino D, Gentiloni N, Murzilli F, Gebreselassie M, La Rocca L M, Patriarca G
Department of Allergology, Catholic University, Rome, Italy.
Allergol Immunopathol (Madr). 1990 Jul-Aug;18(4):233-6.
A case of episodic angioedema with hypereosinophilia or otherwise called Gleich's syndrome is reported. The patient was a young woman with a six-year history of recurrent angioedema, itchy urticaria, rapid weight gain and hypereosinophilia. The main clinical, laboratory, and immunological findings included systemic angioedema, urticaria, 12% weight gain and leucocytosis (69.150 WBC/cu mm) with eosinophils of 75.6%. Circulating IgM, IgE, and T-helper lymphocyte were elevated. Skin biopsy showed an important perivascular eosinophil infiltration. The absence of concomitant allergic, malignant and connective disorders, and a dramatic clinical improvement with a fall of the eosinophil count to normal levels following corticosteroid therapy was the basis for our diagnosis.
报告了一例伴有嗜酸性粒细胞增多的发作性血管性水肿病例，即所谓的格利克综合征。患者为一名年轻女性，有六年复发性血管性水肿、瘙痒性荨麻疹、体重快速增加和嗜酸性粒细胞增多的病史。主要的临床、实验室和免疫学检查结果包括全身性血管性水肿、荨麻疹、体重增加12%以及白细胞增多（白细胞计数为69150/立方毫米），其中嗜酸性粒细胞占75.6%。循环免疫球蛋白M、免疫球蛋白E和辅助性T淋巴细胞升高。皮肤活检显示血管周围有大量嗜酸性粒细胞浸润。排除了同时存在的过敏性、恶性和结缔组织疾病，且皮质类固醇治疗后嗜酸性粒细胞计数降至正常水平，临床症状显著改善，这些是我们做出诊断的依据。
