Fläring U B, Rooyackers O E, Wernerman J, Hammarqvist F
Department of Anaesthesia and Intensive Care, Astrid Lindgren Children's Hospital, Karolinska Hospital, 17176, Stockholm, Sweden.
Department of Anaesthesia and Intensive Care, Huddinge University Hospital, Sweden.
Intensive Care Med. 2003 Dec;29(12):2193-2198. doi: 10.1007/s00134-003-2031-5. Epub 2003 Oct 18.
This study investigated the changes over time in glutathione and its constituent amino acids in skeletal muscle of ICU patients with multiple organ failure.
Prospective and descriptive pilot study in two medium-sized ICUs with ten beds.
Critically ill patients ( n=10) with multiple organ failure and with an expected ICU stay longer than 6 days were included during their initial 3 days after admission to the ICU.
Muscle biopsy and blood samples were taken on days 0, 3, and 6 after inclusion and total, reduced, and oxidized glutathione and the related amino acids were determined. During the study period both total and reduced glutathione increased and was in the normal range on day 6. The constituent amino acids normalized during the study period as well.
This pilot study demonstrates a recovery of muscle glutathione concentrations in critically ill patients with ongoing multiple organ failure within 1 week. Restoration of muscle glutathione seems to be a biological process of high priority in this group of patients.
本研究调查了多器官功能衰竭的重症监护病房（ICU）患者骨骼肌中谷胱甘肽及其组成氨基酸随时间的变化。
在两个拥有十张床位的中型ICU中进行的前瞻性描述性试点研究。
入选多器官功能衰竭且预计在ICU停留时间超过6天的重症患者（n = 10），在其入住ICU后的最初3天内进行研究。
入选后第0、3和6天采集肌肉活检样本和血样，测定总谷胱甘肽、还原型谷胱甘肽、氧化型谷胱甘肽及相关氨基酸。在研究期间，总谷胱甘肽和还原型谷胱甘肽均增加，且在第6天处于正常范围。组成氨基酸在研究期间也恢复正常。
这项试点研究表明，持续存在多器官功能衰竭的重症患者在1周内肌肉谷胱甘肽浓度有所恢复。肌肉谷胱甘肽的恢复似乎是这组患者高度优先的生物学过程。
