Tjäder Inga, Rooyackers Olav, Forsberg Ann-Marie, Vesali Rokhsareh F, Garlick Peter J, Wernerman Jan
Department of Anesthesiology and Intensive Care, Clinical Metabolic Research Center, Department of Clinical Chemistry, Huddinge University Hospital, Karolinska Institutet, SE-141 86 Stockholm, Sweden.
Department of Surgery, State University of New York, Stony Brook, New York, 11794-8191, USA.
Intensive Care Med. 2004 Feb;30(2):266-275. doi: 10.1007/s00134-003-2048-9. Epub 2004 Jan 13.
To evaluate the effect of four doses of intravenous glutamine supplementation on skeletal muscle metabolism.
A prospective, blinded, randomized study.
The general Intensive Care Unit (ICU) of a university hospital.
ICU patients with multiple organ failure (n=40), who were expected to stay in the unit for more than five days.
Patients received 0, 0.28, 0.57 or 0.86 g of glutamine per kg bodyweight per day intravenously for five days as part of an isocaloric, isonitrogenous and isovolumetric diet.
Plasma glutamine concentration responded to glutamine supplementation with normalization of plasma levels in a dose-dependent way, while free muscle glutamine concentration, as well as muscle protein synthesis and muscle protein content, did not change significantly.
Intravenous glutamine supplementation to ICU patients for a period of five days resulted in normalization of plasma glutamine concentrations in a dose-dependent way whereas muscle glutamine concentrations were unaffected.
评估四种剂量静脉补充谷氨酰胺对骨骼肌代谢的影响。
一项前瞻性、盲法、随机研究。
一所大学医院的综合重症监护病房（ICU）。
患有多器官功能衰竭的ICU患者（n = 40），预计在该病房停留超过五天。
作为等热量、等氮量和等容量饮食的一部分，患者每天静脉注射0、0.28、0.57或0.86克每千克体重的谷氨酰胺，持续五天。
血浆谷氨酰胺浓度对谷氨酰胺补充有反应，血浆水平以剂量依赖方式恢复正常，而游离肌肉谷氨酰胺浓度以及肌肉蛋白质合成和肌肉蛋白质含量没有显著变化。
对ICU患者静脉补充谷氨酰胺五天导致血浆谷氨酰胺浓度以剂量依赖方式恢复正常，而肌肉谷氨酰胺浓度未受影响。
