McMartin D N
Thromb Haemost. 1977 Aug 31;38(2):447-56.
Many of the aging Syrian hamsters maintained in our Division spontaneously develop atrial thrombosis accompanied by a consumption coagulopathy. The 50% mortality level is reached earlier by females (16 months) than by males (24 months). The incidence of thrombosis increases with age, beginning at 13.5 months in females and at 21.5 months in males, and the overall incidence (73%) is nearly the same for both sexes. Bilateral ventricular hypertrophy was found in thrombosed hearts. The hearts of most aged hamsters, whether thrombosed or not, had myxoid valvular thickenings and myocardial degeneration. Myodystrophic changes included hypertrophied nuclei, cytoplasmic vacuolation, fiber atrophy, and finally replacement fibrosis. Thrombosis probably resulted from local blood stasis secondary to cardiac failure. These hamsters may be an especially useful model for comparative study of the effects of aging and myocardial degeneration on spontaneous thrombosis.
我们科室饲养的许多老龄叙利亚仓鼠会自发形成心房血栓，并伴有消耗性凝血病。雌性仓鼠（16个月）比雄性仓鼠（24个月）更早达到50%的死亡率。血栓形成的发生率随年龄增长而增加，雌性从13.5个月开始，雄性从21.5个月开始，两性的总体发生率（73%）几乎相同。在有血栓的心脏中发现了双侧心室肥大。大多数老龄仓鼠的心脏，无论是否有血栓，都有黏液样瓣膜增厚和心肌变性。肌营养不良变化包括细胞核肥大、细胞质空泡化、纤维萎缩，最终出现替代性纤维化。血栓形成可能是心力衰竭继发局部血流淤滞所致。这些仓鼠可能是用于比较衰老和心肌变性对自发性血栓形成影响的特别有用的模型。
