Doi K, Yamamoto T, Isegawa N, Doi C, Mitsuoka T
Lab Anim. 1987 Jul;21(3):241-8. doi: 10.1258/002367787781268765.
Spontaneous cardiac and renal lesions in APA hamsters were examined histopathologically. Myocardial degeneration, valvular thickening, coronary arterial degeneration and increase in heart weight were common in old hamsters. These changes, which suggest cardiac failure, seem to be related to cardiac thrombosis which predominantly affected the left atrium and was found in over 40% of each sex over 16 months of age. Neither glomerular amyloidosis nor arteriolar nephrosclerosis was detected. In general the histopathology of renal lesions in APA hamsters resembled that of the condition known as glomerulonephrosis in rats. Renal lesions occurred more frequently and more severely and developed more rapidly in females than in males. There was no apparent correlation between cardiac thrombosis and renal disease.
对 APA 仓鼠的自发性心脏和肾脏病变进行了组织病理学检查。老年仓鼠常见心肌变性、瓣膜增厚、冠状动脉变性和心脏重量增加。这些提示心力衰竭的变化似乎与心脏血栓形成有关，心脏血栓形成主要影响左心房，在 16 个月以上的各性别仓鼠中，发生率超过 40%。未检测到肾小球淀粉样变性和小动脉性肾硬化。一般来说，APA 仓鼠肾脏病变的组织病理学与大鼠的肾小球肾炎相似。雌性仓鼠的肾脏病变比雄性更频繁、更严重且发展更快。心脏血栓形成与肾脏疾病之间没有明显关联。
