Dodds W J, Raymond S L, Moynihan A C, McMartin D N
Thromb Haemost. 1977 Aug 31;38(2):457-64.
Coagulation and fibrinolysis were studied in a colony of aged Syrian hamsters with spontaneous atrial thrombosis, and the results are consistent with concomitant consumption coagulopathy. In comparison to age- and sex-matched hamsters from the same colony, those with atrial thrombi had significantly prolonged prothrombin and partial thromboplastin times, reduced levels of factors II, VII, VIII and X activities and plasminogen; and concentrations of fibrinogen-fibrin split products in excess of 80 microgram/ml. Hematocrits of the thrombosed animals were significantly decreased, total plasma proteins were increased, leukocyte counts were within normal limits, and platelet counts were about half those of the controls. Thrombosed hamsters had significantly reduced plasma albumin content, increased alpha1-, beta-, and gamma-globulins, and reduced A/G ratios. Aged sick hamsters demonstrable thrombi also had reduced coagulation and fibrinolytic activities and platelet counts, but their fibrinogen levels were markedly elevated, and fibrinogen-fibrin split products were either absent or present in trace amounts. This suggests an earlier and/or less acute form of the thrombotic process.
对一群患有自发性心房血栓形成的老年叙利亚仓鼠的凝血和纤维蛋白溶解进行了研究，结果与伴随的消耗性凝血病一致。与来自同一群体的年龄和性别匹配的仓鼠相比，患有心房血栓的仓鼠凝血酶原时间和部分凝血活酶时间显著延长，因子II、VII、VIII和X活性以及纤溶酶原水平降低；纤维蛋白原 - 纤维蛋白裂解产物浓度超过80微克/毫升。血栓形成动物的血细胞比容显著降低，总血浆蛋白增加，白细胞计数在正常范围内，血小板计数约为对照组的一半。血栓形成的仓鼠血浆白蛋白含量显著降低，α1 -、β - 和γ - 球蛋白增加，A/G比值降低。患有明显血栓的老年患病仓鼠的凝血和纤维蛋白溶解活性以及血小板计数也降低，但其纤维蛋白原水平显著升高，纤维蛋白原 - 纤维蛋白裂解产物要么不存在，要么仅微量存在。这表明血栓形成过程的早期和/或不太急性的形式。
