Wilson B D, Mang T S, Stoll H, Jones C, Cooper M, Dougherty T J
Department of Dermatology, Roswell Park Cancer Institute, Buffalo, NY 14263.
Arch Dermatol. 1992 Dec;128(12):1597-601.
Photodynamic therapy is an investigational method for the treatment of a variety of solid tumors. The purpose of this study was to determine the optimum factors and illustrate the effectiveness of photodynamic therapy in the treatment of basal cell carcinomas. This was a prospective study in which patients presenting with primary or recurrent basal cell tumors, particularly but not exclusively widespread tumors or large single tumors, were offered the option of photodynamic therapy in their treatment regimen.
Patients were administered 1 mg/kg of a photosensitizer (Photofrin II). Light doses (630 nm) ranged from 72 to 288 J/cm2. A total of 37 patients with 151 sites were treated in this study. A complete response rate of 88% was achieved with one application. Morbidity was low; the most significant side effects were moderate pain and edema.
Photodynamic therapy is a modality that offers localized treatment of primary or recurrent nonmelanoma skin cancer. By applying reciprocal doses of photosensitizer and light, the efficacy of photodynamic therapy in the treatment of skin lesions is demonstrated achieving significant light penetration into tissue with a high complete response rate of the lesions and acceptable normal tissue response.
光动力疗法是一种用于治疗多种实体瘤的研究性方法。本研究的目的是确定最佳因素，并阐明光动力疗法治疗基底细胞癌的有效性。这是一项前瞻性研究，研究对象为患有原发性或复发性基底细胞瘤的患者，特别是但不限于广泛分布的肿瘤或单个大肿瘤，这些患者在治疗方案中可选择光动力疗法。
患者接受1mg/kg的光敏剂（卟吩姆钠）治疗。光剂量（630nm）范围为72至288J/cm²。本研究共治疗了37例患者的151个部位。单次治疗的完全缓解率达到88%。发病率较低；最显著的副作用是中度疼痛和水肿。
光动力疗法是一种可对原发性或复发性非黑素瘤皮肤癌进行局部治疗的方式。通过给予光敏剂和光的相互剂量，证明了光动力疗法在治疗皮肤病变方面的有效性，该疗法能使光显著穿透组织，病变的完全缓解率高，且正常组织反应可接受。
