Uchida Naohiko, Ujike Hiroshi, Nakata Kenji, Takaki Manabu, Nomura Akira, Katsu Takeshi, Tanaka Yuji, Imamura Takaki, Sakai Ayumu, Kuroda Shigetoshi
Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, Shikata-cho 2-5-1, Okayama, 700-8558, Japan.
BMC Psychiatry. 2003 Oct 21;3:13. doi: 10.1186/1471-244X-3-13.
Several lines of evidence have supported possible roles of the sigma receptors in the etiology of schizophrenia and mechanisms of antipsychotic efficacy. An association study provided genetic evidence that the sigma receptor type 1 gene (SIGMAR1) was a possible susceptibility factor for schizophrenia, however, it was not replicated by a subsequent study. It is necessary to evaluate further the possibility that the SIGMAR1 gene is associated with susceptibility to schizophrenia.
A case-control association study between two polymorphisms of the SIGMAR1 gene, G-241T/C-240T and Gln2Pro, and schizophrenia in Japanese population, and meta-analysis including present and previous studies.
There was no significant association of any allele or genotype of the polymorphisms with schizophrenia. Neither significant association was observed with hebephrenic or paranoid subtype of schizophrenia. Furthermore, a meta-analysis including the present and previous studies comprising 779 controls and 636 schizophrenics also revealed no significant association between the SIGMAR1 gene and schizophrenia.
In view of this evidence, it is likely that the SIGMAR1 gene does not confer susceptibility to schizophrenia.
有几条证据支持西格玛受体在精神分裂症病因学及抗精神病药物疗效机制中可能发挥的作用。一项关联研究提供了基因证据，表明1型西格玛受体基因（SIGMAR1）可能是精神分裂症的一个易感因素，然而，随后的一项研究并未重复这一结果。有必要进一步评估SIGMAR1基因与精神分裂症易感性相关的可能性。
在日本人群中开展一项病例对照关联研究，研究SIGMAR1基因的两个多态性位点G-241T/C-240T和Gln2Pro与精神分裂症之间的关系，并对本研究及之前的研究进行荟萃分析。
这些多态性位点的任何等位基因或基因型与精神分裂症均无显著关联。在精神分裂症的青春型或偏执型亚型中也未观察到显著关联。此外，一项纳入本研究及之前研究（包括779名对照和636名精神分裂症患者）的荟萃分析也显示，SIGMAR1基因与精神分裂症之间无显著关联。
鉴于这些证据，SIGMAR1基因可能不会导致精神分裂症易感性。
