Bushman Frederic D
Infectious Disease Laboratory, The Salk Institute, 10010 North Torrey Pines Rd., La Jolla, CA 92037, USA.
Cell. 2003 Oct 17;115(2):135-8. doi: 10.1016/s0092-8674(03)00760-8.
Replication of retroviruses and retrotransposons depends on selecting a favorable chromosomal site for integration of their genomic DNA. Different retroelements meet this challenge by targeting distinctive chromosomal regions. Despite these differences, recent data hints at a common targeting mechanism-tethering of integration complexes to proteins bound at favorable sites.
逆转录病毒和逆转座子的复制依赖于为其基因组DNA的整合选择一个有利的染色体位点。不同的逆转元件通过靶向不同的染色体区域来应对这一挑战。尽管存在这些差异，但最近的数据暗示了一种共同的靶向机制——将整合复合物与结合在有利位点的蛋白质相连。
