用于药物递送的可生物降解电纺纤维。
Biodegradable electrospun fibers for drug delivery.
作者信息
Zeng Jing, Xu Xiaoyi, Chen Xuesi, Liang Qizhi, Bian Xinchao, Yang Lixin, Jing Xiabin
机构信息
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
出版信息
J Control Release. 2003 Oct 30;92(3):227-31. doi: 10.1016/s0168-3659(03)00372-9.
The influences of surfactants and medical drugs on the diameter size and uniformity of electrospun poly(L-lactic acid) (PLLA) fibers were examined by adding various surfactants (cationic, anionic, and nonionic) and typical drugs into the PLLA solution. Significant diameter reduction and uniformity improvement were observed. It was shown that the drugs were capsulated inside of the fibers and the drug release in the presence of proteinase K followed nearly zero-order kinetics due to the degradation of the PLLA fibers. Such ultrafine fiber mats containing drugs may find clinical applications in the future.
通过向聚左旋乳酸（PLLA）溶液中添加各种表面活性剂（阳离子型、阴离子型和非离子型）和典型药物，研究了表面活性剂和药物对静电纺丝PLLA纤维直径大小和均匀性的影响。观察到纤维直径显著减小且均匀性提高。结果表明，药物被包裹在纤维内部，由于PLLA纤维的降解，在蛋白酶K存在的情况下药物释放遵循近似零级动力学。这种含有药物的超细纤维垫未来可能会有临床应用。
Zotero 插件