Kou Jiaxi, Li Yaodong, Zhou Chen, Wang Xiyu, Ni Jian, Lin Yue, Ge Huaqiang, Zheng Dongfeng, Chen Guopu, Sun Xitai, Tan Qian
Department of Burns and Plastic Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.
Department of Pancreatic and Metabolic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Front Bioeng Biotechnol. 2025 Mar 6;13:1550553. doi: 10.3389/fbioe.2025.1550553. eCollection 2025.
In the field of wound treatment, chronic wounds pose a significant burden on the medical system, affecting millions of patients annually. Current treatment methods often fall short in promoting effective wound healing, highlighting the need for innovative approaches. Electrospinning, a technique that has garnered increasing attention in recent years, shows promise in wound care due to its unique characteristics and advantages. Recent studies have explored the use of electrospun nanofibers in wound healing, demonstrating their efficacy in promoting cell growth and tissue regeneration. Researchers have investigated various materials for electrospinning, including polymers, ceramics, carbon nanotubes (CNTs), and metals. Hydrogel, as a biomaterial that has been widely studied in recent years, has the characteristics of a cell matrix. When combined with electrospinning, it can be used to develop wound dressings with multiple functions. This article is a review of the application of electrospinning technology in the field of wound treatment. It introduces the current research status in the areas of wound pathophysiology, electrospinning preparation technology, and dressing development, hoping to provide references and directions for future research.
在伤口治疗领域，慢性伤口给医疗系统带来了沉重负担，每年影响数百万患者。目前的治疗方法在促进有效伤口愈合方面往往存在不足，凸显了创新方法的必要性。静电纺丝是近年来受到越来越多关注的一种技术，由于其独特的特性和优势，在伤口护理方面显示出前景。最近的研究探索了静电纺丝纳米纤维在伤口愈合中的应用，证明了它们在促进细胞生长和组织再生方面的功效。研究人员研究了用于静电纺丝的各种材料，包括聚合物、陶瓷、碳纳米管（CNTs）和金属。水凝胶作为近年来被广泛研究的一种生物材料，具有细胞基质的特性。当与静电纺丝结合时，它可用于开发具有多种功能的伤口敷料。本文是对静电纺丝技术在伤口治疗领域应用的综述。它介绍了伤口病理生理学、静电纺丝制备技术和敷料开发等领域的当前研究现状，希望为未来的研究提供参考和方向。
