Firbank M J, Colloby S J, Burn D J, McKeith I G, O'Brien J T
Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK.
Neuroimage. 2003 Oct;20(2):1309-19. doi: 10.1016/S1053-8119(03)00364-1.
Tc99 HMPAO SPECT and T1 weighted 3D MRI scans were acquired in cognitively intact subjects with Parkinson's disease (PD) (n = 31), and in PD subjects with dementia (PDD) (n = 34), healthy controls (n = 37), those with Alzheimer's disease (AD) (n = 32), and those with dementia with Lewy bodies (DLB) (n = 15). We used SPM99 to look for regions which showed a reduction in perfusion on SPECT not related to associated structural brain changes assessed by a MRI scan. The precuneus and inferior lateral parietal regions showed a perfusion deficit in Parkinson's disease with dementia, similar to the pattern observed in DLB. In comparison, AD showed a perfusion deficit in the midline parietal region, in a more anterior and inferior location than in PDD, involving the posterior cingulate as well as the precuneus. The perfusion deficits in PDD are similar those in DLB, and in a location associated with visual processing, and may be associated with the visuospatial perception deficits which are present in persons with DLB and PDD.
对认知功能完好的帕金森病（PD）患者（n = 31）、帕金森病痴呆（PDD）患者（n = 34）、健康对照者（n = 37）、阿尔茨海默病（AD）患者（n = 32）以及路易体痴呆（DLB）患者（n = 15）进行了锝-99 六甲基丙二胺肟单光子发射计算机断层扫描（Tc99 HMPAO SPECT）和三维 T1 加权磁共振成像（MRI）扫描。我们使用统计参数映射软件 99（SPM99）来寻找那些在 SPECT 上显示灌注减少且与 MRI 扫描评估的相关脑结构变化无关的区域。楔前叶和顶叶外侧下部区域在帕金森病痴呆中显示灌注不足，类似于在 DLB 中观察到的模式。相比之下，AD 在顶叶中线区域显示灌注不足，位置比 PDD 更靠前和靠下，累及后扣带回以及楔前叶。PDD 中的灌注不足与 DLB 中的相似，且位于与视觉处理相关的位置，可能与 DLB 和 PDD 患者存在的视觉空间感知缺陷有关。
