Jaya C, Job Anand, Mathai Elizabeth, Antonisamy B
Department of Otorhinolaryngology and Head and Neck Surgery, Christian Medical College, Vellore, India.
Arch Otolaryngol Head Neck Surg. 2003 Oct;129(10):1098-100. doi: 10.1001/archotol.129.10.1098.
To evaluate if povidone-iodine (PVP-I) can be used topically in the treatment of chronic suppurative otitis media-tubotympanic disease and to compare it with ciprofloxacin hydrochloride ear drops.
Prospective double-blind randomized study.
Academic tertiary medical center.
Forty patients with chronic suppurative otitis media were randomized into 2 groups.
One group (19 patients) received 5% PVP-I ear drops, while the other group (21 patients) received 0.3% ciprofloxacin ear drops. Both were administered topically, 3 drops 3 times daily for 10 days. These patients were followed up at weekly intervals for up to 4 weeks after commencing therapy.
Clinical improvement at the end of study was 88% in the PVP-I group and 90% in the ciprofloxacin group. The most commonly isolated organism was Pseudomonas aeruginosa. In vitro resistance to ciprofloxacin was seen in 17% of organisms, while no resistance was seen for PVP-I.
To our knowledge, this is the first study to evaluate the efficacy of PVP-I as a topical agent in the treatment of chronic suppurative otitis media. The results show that clinically, topical PVP-I is as effective as topical ciprofloxacin, with a superior advantage of having no in vitro drug resistance. Also, there is an added benefit of reduced cost of therapy.
评估聚维酮碘（PVP-I）是否可局部用于治疗慢性化脓性中耳炎-咽鼓管鼓室型疾病，并将其与盐酸环丙沙星滴耳液进行比较。
前瞻性双盲随机研究。
学术性三级医疗中心。
40例慢性化脓性中耳炎患者被随机分为2组。
一组（19例患者）接受5%聚维酮碘滴耳液，另一组（21例患者）接受0.3%环丙沙星滴耳液。均局部给药，每日3次，每次3滴，共10天。这些患者在开始治疗后每周随访一次，最长随访4周。
研究结束时，聚维酮碘组的临床改善率为88%，环丙沙星组为90%。最常分离出的病原体是铜绿假单胞菌。17%的病原体对环丙沙星有体外耐药性，而聚维酮碘未观察到耐药性。
据我们所知，这是第一项评估聚维酮碘作为局部用药治疗慢性化脓性中耳炎疗效的研究。结果表明，在临床上，局部使用聚维酮碘与局部使用环丙沙星一样有效，且具有体外无耐药性的优势。此外，还有治疗成本降低的额外益处。
