[环丙沙星对慢性化脓性中耳炎的局部治疗]
[Local treatment of purulent chronic otitis media with ciprofloxacin].
作者信息
Podoshin L, Brodzki A, Fradis M, Ben-David J, Larboni J, Srugo I
机构信息
Dept. of Otolaryngology, Head and Neck Surgery, Bnai-Zion Medical Center, Technion, Haifa.
出版信息
Harefuah. 1998 Jan 1;134(1):32-6, 78.
We evaluated the efficacy of ciprofloxacin eardrops compared to tobramycin and to a placebo in the treatment of chronic suppurative otitis media. 60 ears were randomly assigned to treatment for 3 weeks with ciprofloxacin, tobramycin or placebo eardrops. The organism most commonly isolated from the ear discharge was Pseudomonas aeruginosa. The clinical responses were 78.9% and 72.2%, respectively, in the ciprofloxacin and tobramycin groups, while it was only 41.2% in the placebo group. Treatment with ciprofloxacin eardrops seemed to be at least as efficient as treatment with tobramycin. Considering the lack of ototoxicity of ciprofloxacin, this treatment may be best for chronic otitis media.
我们评估了环丙沙星耳滴剂与妥布霉素及安慰剂相比，在治疗慢性化脓性中耳炎方面的疗效。60只耳朵被随机分配，分别用环丙沙星、妥布霉素或安慰剂耳滴剂治疗3周。从耳分泌物中最常分离出的病原体是铜绿假单胞菌。环丙沙星组和妥布霉素组的临床有效率分别为78.9%和72.2%，而安慰剂组仅为41.2%。环丙沙星耳滴剂治疗似乎至少与妥布霉素治疗一样有效。考虑到环丙沙星没有耳毒性，这种治疗方法可能是慢性中耳炎的最佳选择。
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