Pannacciulli Nicola, Giorgino Francesco, Martina Raffaele A, Resta Onofrio, Giorgino Riccardo, De Pergola Giovanni
Internal Medicine, Endocrinology, and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.
Obes Res. 2003 Oct;11(10):1232-7. doi: 10.1038/oby.2003.169.
To evaluate the effect of a first-degree family history of type 2 diabetes on white blood cell (WBC) count, a risk factor for atherosclerotic vascular disease, in glucose-tolerant adult women.
WBC count was measured in 174 normal weight, overweight, and obese female offspring of type 2 diabetic patients (FH(+)) and 174 age- and BMI-matched female controls with no family history of type 2 diabetes (FH(-)). Other measurements included fat mass (FM), measured by body impedance analysis; central fat accumulation, evaluated by waist circumference; insulin resistance, estimated by homeostatic model assessment for insulin resistance (HOMA(IR)); systolic and diastolic blood pressure; and fasting concentrations of glucose, insulin, and lipids.
WBC count, waist circumference, systolic blood pressure, and fasting levels of glucose, insulin, and triglycerides were significantly higher in FH(+) than in FH(-) subjects. In FH(+) individuals, WBC count was positively associated with BMI, FM, waist circumference, HOMA(IR), and triglyceride and insulin concentrations, and negatively correlated with age and high-density lipoprotein-cholesterol. In FH(-) subjects, WBC count was directly associated with BMI, FM, waist circumference, and triglyceride and insulin concentrations, and inversely correlated with age and high-density lipoprotein-cholesterol. After multivariate analyses, WBC count maintained a significant association with age, systolic blood pressure, and HOMA(IR) in FH(+) subjects and with age, BMI, FM, and triglycerides in FH(-) individuals.
This study indicates that WBC count is increased in adult women with genetic predisposition to type 2 diabetes, and its main correlates are insulin resistance in FH(+) and adiposity in FH(-) individuals.
评估2型糖尿病一级家族史对糖耐量正常成年女性白细胞（WBC）计数的影响，白细胞计数是动脉粥样硬化性血管疾病的一个危险因素。
对174名2型糖尿病患者的正常体重、超重和肥胖女性后代（FH(+)）以及174名年龄和体重指数匹配、无2型糖尿病家族史的女性对照者（FH(-)）进行白细胞计数测量。其他测量指标包括通过人体阻抗分析测量的脂肪量（FM）；通过腰围评估的中心脂肪堆积；通过胰岛素抵抗稳态模型评估（HOMA(IR)）估算的胰岛素抵抗；收缩压和舒张压；以及空腹血糖、胰岛素和血脂浓度。
FH(+)组的白细胞计数、腰围、收缩压以及空腹血糖、胰岛素和甘油三酯水平均显著高于FH(-)组。在FH(+)个体中，白细胞计数与体重指数、脂肪量、腰围、HOMA(IR)以及甘油三酯和胰岛素浓度呈正相关，与年龄和高密度脂蛋白胆固醇呈负相关。在FH(-)组中，白细胞计数与体重指数、脂肪量、腰围以及甘油三酯和胰岛素浓度直接相关，与年龄和高密度脂蛋白胆固醇呈负相关。多因素分析后，FH(+)组中白细胞计数与年龄、收缩压和HOMA(IR)仍保持显著关联，而在FH(-)个体中与年龄、体重指数、脂肪量和甘油三酯保持显著关联。
本研究表明，有2型糖尿病遗传易感性的成年女性白细胞计数升高，其主要相关因素在FH(+)个体中是胰岛素抵抗，在FH(-)个体中是肥胖。
