Halkjaer Jytte, Holst Claus, Sørensen Thorkild I A
Danish Epidemiology Science Centre at the Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark.
Obes Res. 2003 Oct;11(10):1238-45. doi: 10.1038/oby.2003.170.
To investigate whether intelligence and education are related to subsequent BMI changes and development and persistence of obesity in men from young adulthood through middle-age.
Subjects were selected among men (median age, 19 years; examined between 1956 and 1977) appearing at Danish draft boards: a group with juvenile-onset obesity, including all men with a BMI of >/=31.0 kg/m(2); and a nonobese group randomly selected as a 1% sample of the study population. The obese group and 50% of the nonobese group were invited to participate in follow-up studies between 1982 and 1984 and between 1992 and 1994. Among 907 men with juvenile-onset obesity and 883 nonobese men, age, examination region, intelligence test score, education, and BMI from baseline to first follow-up were analyzed by multiple linear and logistic regressions analyses.
Education and intelligence, analyzed separately, were inversely related to BMI changes in both groups and to the development of obesity in the nonobese group. When adjusted for education, the association between intelligence score and BMI changes and development of obesity vanished, whereas the inverse relationship for education persisted only for BMI changes. Intelligence score was not associated with the persistence of obesity in the obese group, whereas inverse relationships were found for education.
Intelligence test score was inversely related to risk of BMI changes and the risk of development of obesity, perhaps with education acting as a mediator or indicator of cognitive ability. Education, but not intelligence, was inversely associated with risk of remaining obese.
研究从青年期到中年男性的智力和教育程度是否与随后的体重指数（BMI）变化以及肥胖的发生和持续存在有关。
研究对象选自丹麦征兵委员会登记的男性（中位年龄19岁；于1956年至1977年接受检查）：一组为青少年期起病的肥胖者，包括所有BMI≥31.0kg/m²的男性；另一组为非肥胖组，作为研究人群的1%随机选取。肥胖组和50%的非肥胖组被邀请参加1982年至1984年以及1992年至1994年的随访研究。对907名青少年期起病的肥胖男性和883名非肥胖男性，采用多元线性回归和逻辑回归分析方法，分析了从基线到首次随访时的年龄、检查地区、智力测试得分、教育程度和BMI。
分别分析时，教育程度和智力在两组中均与BMI变化以及非肥胖组肥胖的发生呈负相关。调整教育程度后，智力得分与BMI变化及肥胖发生之间的关联消失，而教育程度与BMI变化之间的负相关关系仍然存在。肥胖组中智力得分与肥胖的持续存在无关，而教育程度与肥胖持续存在呈负相关。
智力测试得分与BMI变化风险及肥胖发生风险呈负相关，教育程度可能起到认知能力的中介或指标作用。教育程度而非智力与持续肥胖的风险呈负相关。
