长期肥胖与抑郁和神经炎症有关。
Long-term obesity is associated with depression and neuroinflammation.
机构信息
Programa de Distúrbios do Desenvolvimento, Centro de Ciências Biológicas e da Saúde, Universidade Presbiteriana Mackenzie, São Paulo, SP, Brasil.
Medicina Translacional, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
出版信息
Arch Endocrinol Metab. 2021 Oct 29;65(5):537-548. doi: 10.20945/2359-3997000000400.
OBJECTIVE
Obesity is characterized by a state of chronic, low-intensity systemic inflammation frequently associated with insulin resistance and dyslipidemia.
METHODS
Given that chronic inflammation has been implicated in the pathogenesis of mood disorders, we investigated if chronic obesity that was initiated early in life - lasting through adulthood - could be more harmful to memory impairment and mood fluctuations such as depression.
RESULTS
Here we show that pre-pubertal male rats (30 days old) treated with a high-fat diet (40%) for 8-months gained ~50% more weight when compared to controls, exhibited depression and anxiety-like behaviors but no memory impairment. The prefrontal cortex of the obese rats exhibited an increase in the expression of genes related to inflammatory response, such as NFKb, MMP9, CCl2, PPARb, and PPARg. There were no alterations in genes known to be related to depression.
CONCLUSION
Long-lasting obesity with onset in prepuberal age led to depression and neuroinflammation but not to memory impairment.
目的
肥胖的特征是一种慢性、低强度的全身炎症状态，常伴有胰岛素抵抗和血脂异常。
方法
鉴于慢性炎症与情绪障碍的发病机制有关，我们研究了如果肥胖是在生命早期开始的——持续到成年——是否会对记忆障碍和情绪波动（如抑郁）造成更大的危害。
结果
在这里，我们发现，30 天大的雄性幼鼠（pre-pubertal）接受高脂肪饮食（40%）治疗 8 个月后，体重增加了约 50%，表现出抑郁和焦虑样行为，但没有记忆障碍。肥胖大鼠的前额叶皮层表现出与炎症反应相关的基因表达增加，如 NFKb、MMP9、CCl2、PPARb 和 PPARg。没有发现与抑郁相关的基因发生改变。
结论
青春期前开始的长期肥胖会导致抑郁和神经炎症，但不会导致记忆障碍。
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