Mannino David M, Albalak Rachel, Grosse Scott, Repace James
Air Pollution and Respiratory Health Branch, Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Epidemiology. 2003 Nov;14(6):719-27. doi: 10.1097/01.EDE.0000081998.02432.53.
Lead is a component of tobacco and tobacco smoke, and smokers have higher blood lead levels than do nonsmokers.
We examined the relation between second-hand smoke exposure and blood lead levels in a nationally representative sample of 5592 U.S. children, age 4-16 years, who participated in the Third National Health and Nutrition Examination Survey (1988-1994). Linear and logistic regression modeling was used to adjust for known covariates.
Geometric mean blood lead levels were 1.5 mug/dL, 1.9 mug/dL, and 2.6 mug/dL for children with low, intermediate, and high cotinine levels, respectively. The adjusted linear regression model showed that geometric mean blood lead levels were 38% higher (95% confidence interval [CI] = 25-52%) in children with high cotinine levels compared with children who had low cotinine levels. The logistic regression models showed that children with high cotinine levels were more likely to have blood lead levels >/=10 mug/dL than were children with low cotinine levels (odds ratio [OR] = 4.4; CI = 1.9-10.5).
Second-hand smoke could be associated with increased blood lead levels in U.S. children aged 4-16 years.
铅是烟草和烟草烟雾的成分之一，吸烟者的血铅水平高于非吸烟者。
我们在美国5592名4至16岁儿童的全国代表性样本中研究了二手烟暴露与血铅水平之间的关系，这些儿童参与了第三次全国健康和营养检查调查（1988 - 1994年）。使用线性和逻辑回归模型对已知协变量进行调整。
可替宁水平低、中、高的儿童的几何平均血铅水平分别为1.5微克/分升、1.9微克/分升和2.6微克/分升。调整后的线性回归模型显示，与可替宁水平低的儿童相比，可替宁水平高的儿童的几何平均血铅水平高38%（95%置信区间[CI]=25 - 52%）。逻辑回归模型显示，可替宁水平高的儿童血铅水平≥10微克/分升的可能性高于可替宁水平低的儿童（比值比[OR]=4.4；CI = 1.9 - 10.5）。
二手烟可能与美国4至16岁儿童血铅水平升高有关。
