Shumakov V I, Onishchenko N A, Rasulov M F, Krasheninnikov M E, Zaĭdenov V A
Vestn Khir Im I I Grek. 2003;162(4):38-42.
The opportunity of faster closing deep burn wounds by using fibroblast-like mesenchymal bone marrow stem cells (FMSC) and embryonic fibroblasts (EF) was investigated in rats. It was shown that FMSC as well as EF transplanted onto burn surfaces reduced the expression of cell infiltration but accelerated the formation of vessels de novo and granulation tissue in the wounds. These changes form the conditions for faster closing the burn wounds as compared to the control wounds (without cell transplantation). High rate of wound closing induced by FMSC and EF is thought to be caused by a long period (up to 30 days) of vital activity of the cells grafted on the burn surface. It was also found out that the rate of wound regeneration induced by FMSC was higher that that induced by EF.
在大鼠中研究了使用成纤维细胞样间充质骨髓干细胞（FMSC）和胚胎成纤维细胞（EF）更快闭合深度烧伤创面的可能性。结果表明，移植到烧伤表面的FMSC和EF均降低了细胞浸润的表达，但加速了伤口处新生血管和肉芽组织的形成。与对照伤口（未进行细胞移植）相比，这些变化为更快闭合烧伤创面创造了条件。FMSC和EF诱导的高伤口闭合率被认为是由于移植到烧伤表面的细胞具有长达30天的存活期。还发现，FMSC诱导的伤口再生速率高于EF诱导的伤口再生速率。
