Sukhotina Irina A, Malyshkin Andrey A, Markou Athina, Bespalov Anton Y
Institute of Pharmacology, Lab of Behavioral Pharmacology, Pavlov Medical University, 6/8 Lev Tolstoy Street, St Petersburg 197089, Russia.
Behav Neurosci. 2003 Oct;117(5):970-7. doi: 10.1037/0735-7044.117.5.970.
In humans and laboratory animals, drug withdrawal often is associated with depression-like behaviors. In the present study, rats had unlimited free-choice access to water and a saccharin-containing solution before being subjected to repeated episodes of saccharin deprivation. Saccharin deprivation (1) reduced immobility time in the forced swim test, (2) increased reinforcement rate in rats trained to lever-press under the differential reinforcement of a low-rate (72-sec) schedule of food reinforcement, and (3) lowered intracranial self-stimulation thresholds in a discrete-trial current titration procedure. Taken together, these findings suggest that deprivation from a nondrug reinforcer, saccharin, is not associated with depression-like behaviors. In contrast, saccharin-deprived rats demonstrated improved performance in the behavioral paradigms used here.
在人类和实验动物中，药物戒断通常与类似抑郁的行为有关。在本研究中，大鼠在经历反复的糖精剥夺之前，可以无限制地自由选择饮水和含糖精的溶液。糖精剥夺：(1) 在强迫游泳试验中减少了不动时间；(2) 在接受低频率（72 秒）食物强化差异强化训练以按压杠杆的大鼠中提高了强化率；(3) 在离散试验电流滴定程序中降低了颅内自我刺激阈值。综合来看，这些发现表明，非药物强化物糖精的剥夺与类似抑郁的行为无关。相反，糖精剥夺的大鼠在此处使用的行为范式中表现出了更好的性能。
