Mallick P, Mallick J Chakrabarti, Guha B, Khuda-Bukhsh A R
Department of Zoology, University of Kalyani, Kalyani-741235, WB, India.
BMC Complement Altern Med. 2003 Oct 22;3:7. doi: 10.1186/1472-6882-3-7.
Arsenic in groundwater and its accumulation in plants and animals have assumed a menacing proportion in a large part of West Bengal, India and adjoining areas of Bangladesh. Because of the tremendous magnitude of the problem, there seems to be no way to tackle the problem overnight. Efforts to provide arsenic free water to the millions of people living in these dreaded zones are being made, but are awfully inadequate. In our quest for finding out an easy, safe and affordable means to combat this problem, a homeopathic drug, Arsenicum Album-30, appears to yield promising results in mice. The relative efficacies of two micro doses of this drug, namely, Arsenicum Album-30 and Arsenicum Album-200, in combating arsenic toxicity have been determined in the present study on the basis of some accepted biochemical protocols.
Mice were divided into different sets of control (both positive and negative) and treated series (As-intoxicated, As-intoxicated plus drug-fed). Alanine amino transferase (ALT) and aspartate amino transferase (AST) activities and reduced glutathione (GSH) level in liver and blood were analyzed in the different series of mice at six different fixation intervals.
Both Arsenicum Album-30 and Arsenicum Album-200 ameliorated arsenic-induced toxicity to a considerable extent as compared to various controls.
The results lend further support to our earlier views that microdoses of potentized Arsenicum Album are capable of combating arsenic intoxication in mice, and thus are strong candidates for possible use in human subjects in arsenic contaminated areas under medical supervision.
在印度西孟加拉邦的大部分地区以及孟加拉国的毗邻地区，地下水中的砷及其在动植物体内的蓄积已达到了威胁性的程度。由于该问题规模巨大，似乎无法一蹴而就解决。目前正在努力为生活在这些危险地区的数百万人提供无砷水，但力度远远不够。在我们寻求一种简便、安全且经济实惠的方法来应对这一问题的过程中，一种顺势疗法药物，砷酸白-30，在小鼠身上似乎产生了有希望的结果。在本研究中，基于一些公认的生化实验方案，确定了该药物的两种微量剂量，即砷酸白-30和砷酸白-200，在对抗砷毒性方面的相对功效。
将小鼠分为不同组的对照组（包括阳性和阴性）和处理组（砷中毒组、砷中毒加药物喂养组）。在六个不同的固定时间间隔对不同组小鼠的肝脏和血液中的丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）活性以及还原型谷胱甘肽（GSH）水平进行分析。
与各种对照组相比，砷酸白-30和砷酸白-200都在相当程度上减轻了砷诱导的毒性。
这些结果进一步支持了我们早期的观点，即微量的增效砷酸白能够对抗小鼠体内的砷中毒，因此在医疗监督下，它们很有可能成为砷污染地区人类受试者的用药选择。
