Huang Huimin, Yao Tingjun, Wang Wei, Zhu Deming, Zhang Wei, Chen Hong, Fu Weiding
Department of Thoracocardiac Surgery, Children's Medical Center, Xinhua Hospital, Shanghai Second Medical University, Shanghai 200127, China.
Chin Med J (Engl). 2003 Oct;116(10):1504-7.
To explore the effects of ultrafiltration technique in preventing and relieving pulmonary injury in children undergoing open heart surgery and cardiopulmonary bypass (CPB).
Thirty cases with congenital heart defects were divided into a control group and an experimental group. In the control group, conventional cardiopulmonary bypass was used without ultrafiltration; while in the experimental group, cardiopulmonary bypass with balanced ultrafiltration and modified ultrafiltration were used. Pulmonary static compliance (Cstat), airway resistance (Raw), alveolar-arterial oxygen difference (A-a DO2), hematocrit (HCT), serum albumin (Alb), interleukin-6 (IL-6), endothelia-1 (ET-1) and thromboxane (TXB2) were measured.
The pulmonary function was improved, HCT and serum albumin concentrations were increased, and some harmful medium-size solutes were decreased in the experimental groups compared with the control group.
Combination of balanced ultrafiltration with modified ultrafiltration can effectively concentrate blood, exclude harmful inflammatory mediators, and attenuate lung edema and inflammatory responsive pulmonary injury.
探讨超滤技术在预防和减轻小儿心脏直视手术及体外循环（CPB）中肺损伤的作用。
将30例先天性心脏病患儿分为对照组和实验组。对照组采用常规体外循环，不进行超滤；实验组采用平衡超滤和改良超滤的体外循环。测量肺静态顺应性（Cstat）、气道阻力（Raw）、肺泡 - 动脉血氧分压差（A - a DO2）、血细胞比容（HCT）、血清白蛋白（Alb）、白细胞介素 - 6（IL - 6）、内皮素 - 1（ET - 1）和血栓素（TXB2）。
与对照组相比，实验组肺功能改善，HCT和血清白蛋白浓度升高，一些有害的中分子溶质减少。
平衡超滤与改良超滤联合应用可有效浓缩血液，排除有害炎症介质，减轻肺水肿和炎症反应性肺损伤。
