神经炎症的分子发病机制
Molecular pathogenesis of neuroinflammation.
作者信息
Bradl M, Hohlfeld R
机构信息
Institute for Brain Research, Department of Neuroimmunology, Vienna, Austria.
出版信息
J Neurol Neurosurg Psychiatry. 2003 Oct;74(10):1364-70. doi: 10.1136/jnnp.74.10.1364.
Abstract
The past few years have seen significant progress towards understanding the mechanisms of immune surveillance and inflammation in the nervous system. In this review, the milestones of scientific discovery in this field are discussed, and the strengths and limitations of the different ways of examining the molecular pathogenesis of neuro-inflammation examined. The review is limited to the inflammatory reactions of the central nervous system that occur in multiple sclerosis and experimental autoimmune encephalomyelitis.
摘要
在理解神经系统免疫监视和炎症机制方面，过去几年取得了重大进展。在这篇综述中，我们将讨论该领域科学发现的里程碑，并审视研究神经炎症分子发病机制的不同方法的优缺点。本综述仅限于多发性硬化症和实验性自身免疫性脑脊髓炎中发生的中枢神经系统炎症反应。
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