PATERSON P Y
J Exp Med. 1960 Jan 1;111(1):119-36. doi: 10.1084/jem.111.1.119.
Transfer of allergic encephalomyelitis has been accomplished by injection of lymph node cells, obtained from donor rats sensitized to spinal cord, into recipient rats pretreated neonatally with normal rat spleen cells. Transfer of the disease may be achieved most frequently when the recipients are pretreated with spleen cells of the prospective lymph node cell donors. These transfers are attributed to the use of recipients which have acquired immunological tolerance to donor lymph node cells, as a result of the spleen cell pretreatment, and in which, therefore, the donor cells can survive and function longer after transfer.
通过将从对脊髓致敏的供体大鼠获取的淋巴结细胞注射到新生期用正常大鼠脾细胞预处理的受体大鼠中，已实现变应性脑脊髓炎的转移。当受体用预期的淋巴结细胞供体的脾细胞进行预处理时，疾病转移最常得以实现。这些转移归因于使用了由于脾细胞预处理而对供体淋巴结细胞获得免疫耐受的受体，因此，在这些受体中，供体细胞在转移后能够存活更长时间并发挥作用。
