Seidler A, Bolm-Audorff U, Siol T, Henkel N, Fuchs C, Schug H, Leheta F, Marquardt G, Schmitt E, Ulrich P T, Beck W, Missalla A, Elsner G
Institute of Occupational Medicine, Johann Wolfgang Goethe-University, Frankfurt/Main, Germany.
Occup Environ Med. 2003 Nov;60(11):821-30. doi: 10.1136/oem.60.11.821.
Previous studies mostly did not separate between symptomatic disc herniation combined with osteochondrosis/spondylosis of the lumbar spine and symptomatic disc herniation in radiographically normal intervertebral spaces. This may at least in part explain the differences in the observed risk patterns.
To investigate the possible aetiological relevance of physical and psychosocial workload to lumbar disc herniation with and without concomitant osteochondrosis/spondylosis.
A total of 267 cases with acute lumbar disc herniation (in two practices and four clinics) and 197 control subjects were studied. Data were gathered in a structured personal interview and analysed using logistic regression to control for age, region, nationality, and diseases affecting the lumbar spine. Cases without knowledge about osteochondrosis/spondylosis (n=42) were excluded from analysis. Risk factors were examined separately for those cases with (n=131) and without (n=94) radiographically diagnosed concomitant osteochondrosis or spondylosis.
There was a statistically significant positive association between extreme forward bending and lumbar disc herniation with, as well as without concomitant osteochondrosis/spondylosis. There was a statistically significant relation between cumulative exposure to weight lifting or carrying and lumbar disc herniation with, but not without, concomitant osteochondrosis/spondylosis. Cases with disc herniation reported time pressure at work as well as psychic strain through contact with clients more frequently than control subjects.
Further larger studies are needed to verify the concept of distinct aetiologies of lumbar disc herniation in relatively younger persons with otherwise normal discs and of disc herniation in relatively older persons with structurally damaged discs.
以往的研究大多未区分伴有腰椎骨软骨病/脊椎病的症状性椎间盘突出症与影像学检查显示椎间间隙正常的症状性椎间盘突出症。这可能至少在一定程度上解释了观察到的风险模式差异。
探讨身体和心理社会负荷对伴有或不伴有骨软骨病/脊椎病的腰椎间盘突出症可能的病因学相关性。
对总共267例急性腰椎间盘突出症患者(来自两家诊所和四家门诊部)和197名对照者进行了研究。通过结构化的个人访谈收集数据,并使用逻辑回归分析来控制年龄、地区、国籍以及影响腰椎的疾病。对不了解骨软骨病/脊椎病情况的病例(n = 42)排除在分析之外。分别对影像学诊断伴有(n = 131)和不伴有(n = 94)骨软骨病或脊椎病的病例进行危险因素检查。
极端前屈与伴有或不伴有骨软骨病/脊椎病的腰椎间盘突出症之间存在统计学上显著的正相关。举重或搬运的累积暴露与伴有骨软骨病/脊椎病的腰椎间盘突出症之间存在统计学上显著的关系,但与不伴有骨软骨病/脊椎病的腰椎间盘突出症无关。与对照者相比,椎间盘突出症患者更频繁地报告工作中的时间压力以及与客户接触带来的精神压力。
需要进一步开展更大规模的研究,以验证相对年轻、椎间盘正常者的腰椎间盘突出症以及相对年长、椎间盘结构受损者的椎间盘突出症病因不同这一概念。