Lu X H, Cho D, Hall H, Rowe T, Mo I P, Sung H W, Kim W J, Kang C, Cox N, Klimov A, Katz J M
Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, N.E., Atlanta, GA 30333, USA.
Avian Dis. 2003;47(3 Suppl):1135-40. doi: 10.1637/0005-2086-47.s3.1135.
The outbreak of avian influenza H5N1 in Hong Kong in 1997 raised concerns about the potential for the H5 subtype to cause a human pandemic. In 2001 a new H5N1 virus, A/Duck Meat/Anyang/AVL-1/2001 (A/Dkmt), was isolated from imported duck meat in Korea. The pathogenesis of this virus was investigated in mice. A/Dkmt virus had low infectivity but was lethal for mice at high doses, and at lethal doses, the virus replicated in the brains of infected mice. A/Dkmt virus cross-reacted poorly with ferret antisera raised against human H5N1 viruses, but prior infection with A/Dkmt virus protected mice from death after secondary infection with human H5N1 virus.
1997年香港爆发的H5N1禽流感引发了人们对H5亚型引发人类大流行可能性的担忧。2001年，一种新的H5N1病毒，A/鸭肉/安阳/AVL-1/2001（A/Dkmt），从韩国进口的鸭肉中分离出来。对该病毒在小鼠中的发病机制进行了研究。A/Dkmt病毒感染性低，但高剂量时对小鼠具有致死性，在致死剂量下，该病毒在受感染小鼠的大脑中复制。A/Dkmt病毒与针对人类H5N1病毒产生的雪貂抗血清交叉反应较差，但预先感染A/Dkmt病毒可保护小鼠在二次感染人类H5N1病毒后免于死亡。
