Thomas Sherin S, Chhabra Sunil K
Maulana Azad Medical College, New Delhi 110002.
J Indian Med Assoc. 2003 May;101(5):282, 284, 286 passim.
Mononuclear phagocytes can be activated through an immunoglobulin E (IgE)- specific mechanism to release pro-inflammatory cytokine like interleukin-1beta (IL-1beta). The present study was conducted to show the inter-relationship between these two parameters in the serum of asthmatic patients. The study included 30 patients of asthma and 10 as control. Out of these 30 cases, 20 patients had stable and 10 had acute asthma. Of the 20 stable patients, 9 were allergic and 11 were non-allergic to either of the 12 allergens used for skin prick test. Serum IgE and IL-1beta levels were measured by enzyme linked immunosorbent assay (ELISA). Total serum IgE levels increased significantly (p < 0.05) in asthma [200.5 +/- 30.91 IU/ml, mean +/- standard error of mean (SEM)] in comparison with the controls (18.15 +/- 4.35 IU/ml). Serum IL-1beta level was higher in allergic (1.94 +/- 0.63 pg/ml) than in non-allergic patients (0.64 +/- 0.21 pg/ml) but it was not statistically significant (p > 0.05). The study suggests involvement of IgE and IL-1beta in the pathophysiology of allergic asthmatic condition. Further studies are required to delineate the inflammatory pathway in asthma and determine stages at which therapeutic interventions can be done.
单核吞噬细胞可通过免疫球蛋白E（IgE）特异性机制被激活，从而释放白细胞介素-1β（IL-1β）等促炎细胞因子。本研究旨在揭示哮喘患者血清中这两个参数之间的相互关系。该研究纳入了30例哮喘患者和10例作为对照。在这30例病例中，20例患者病情稳定，10例为急性哮喘。在20例病情稳定的患者中，9例对用于皮肤点刺试验的12种变应原中的任何一种过敏，11例不过敏。采用酶联免疫吸附测定（ELISA）法检测血清IgE和IL-1β水平。与对照组（18.15±4.35 IU/ml）相比，哮喘患者的总血清IgE水平显著升高（p<0.05）[200.5±30.91 IU/ml，平均值±平均标准误差（SEM）]。过敏患者的血清IL-1β水平（1.94±0.63 pg/ml）高于非过敏患者（0.64±0.21 pg/ml），但差异无统计学意义（p>0.05）。该研究提示IgE和IL-1β参与了过敏性哮喘疾病的病理生理过程。需要进一步研究来阐明哮喘中的炎症途径，并确定可以进行治疗干预的阶段。
