Van Staaij Birgit K, Van Den Akker Emma H, De Haas Van Dorsser Elisabeth H M, Fleer Andre, Hoes Arno W, Schilder Anne G M
Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands.
Acta Otolaryngol. 2003 Sep;123(7):873-8. doi: 10.1080/00016480310000395.
To investigate whether the tonsillar flora differ in children with and without adenotonsillar disease.
Tonsil surface swabs were taken from 218 children indicated for adenotonsillectomy because of moderate symptoms of recurrent tonsillopharyngitis or adenotonsillar hypertrophy (T+Ads group). Control swabs were taken from 100 children without symptoms of adenotonsillar disease who visited the ophthalmology clinic. Potential respiratory pathogens were identified.
Potential respiratory pathogens were found in 54% of the T+Ads group, compared to 41% of the control group (p = 0.04). Haemophilus influenzae was the commonest pathogen in both groups, being found in 41% of the T+Ads group and 34% of the control group. Moraxella catarrhalis was found more often in the T+Ads group compared to the control group: 7% vs 0% (p = 0.004). H. influenzae was found in 32% of the children with recurrent tonsillitis, compared to 48% of the children with symptoms of tonsillar hypertrophy (p = 0.03).
The prevalence of potential respiratory pathogens on the tonsillar surface of children with moderate symptoms of recurrent tonsillopharyngitis and/or tonsillar hypertrophy differs only slightly from that in children without symptoms of adenotonsillar disease. Variations in the microbial flora do not seem to play an essential role in the predisposition of these children to tonsillar disease.
探讨患有和未患有腺样体扁桃体疾病的儿童扁桃体菌群是否存在差异。
从218名因复发性扁桃体咽炎或腺样体扁桃体肥大的中度症状而接受腺样体扁桃体切除术的儿童中采集扁桃体表面拭子（T+Ads组）。对照拭子取自100名到眼科门诊就诊且无腺样体扁桃体疾病症状的儿童。鉴定潜在的呼吸道病原体。
T+Ads组中54%发现有潜在呼吸道病原体，而对照组为41%（p = 0.04）。流感嗜血杆菌是两组中最常见的病原体，在T+Ads组中占41%，在对照组中占34%。与对照组相比，卡他莫拉菌在T+Ads组中更常见：分别为7%和0%（p = 0.004）。复发性扁桃体炎患儿中有32%发现有流感嗜血杆菌，而有扁桃体肥大症状的患儿中这一比例为48%（p = 0.03）。
有复发性扁桃体咽炎和/或扁桃体肥大中度症状的儿童扁桃体表面潜在呼吸道病原体的患病率与无腺样体扁桃体疾病症状的儿童相比仅有轻微差异。微生物菌群的差异似乎在这些儿童易患扁桃体疾病方面不起重要作用。
