Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Department of Neurosurgery, St. Vincent Hospital, The Catholic University of Korea, Suwon 16247, Korea.
Cells. 2022 Jul 24;11(15):2285. doi: 10.3390/cells11152285.
Amyloid-β (Aβ)-peptide production or deposition in the neuropathology of Alzheimer's disease (AD) was shown to be caused by chronic inflammation that may be induced by infection, but the role of pathogenic-bacteria-related AD-associated Aβ is not yet clearly understood. In this study, we validated the hypothesis that there is a correlation between the Aβ-protein load and bacterial infection and that there are effects of bacteria, (), on the Aβ load in the inflammatory environment of human tonsils. Here, we detected Aβ-peptide deposits in human tonsil tissue as well as tissue similar to tonsilloliths found in the olfactory cleft. Interestingly, we demonstrated for the first time the presence of () clustered around or embedded in the Aβ deposits. Notably, we showed that treatment with upregulated the Aβ-protein load in cultures of human tonsil organoids and brain organoids, showing the new role of in Aβ-protein aggregation. These findings suggest that a reservoir of Aβ and pathogenic bacteria may be a possible therapeutic target in human tonsils, supporting the treatment of antibiotics to prevent the deposition of Aβ peptides via the removal of pathogens in the intervention of AD pathogenesis.
淀粉样蛋白-β（Aβ）肽在阿尔茨海默病（AD）的神经病理学中的产生或沉积被证明是由慢性炎症引起的，这种炎症可能是由感染引起的，但与致病性细菌相关的 AD 相关 Aβ的作用尚不清楚。在这项研究中，我们验证了以下假设，即 Aβ 蛋白负荷与细菌感染之间存在相关性，并且细菌（）在人扁桃体的炎症环境中对 Aβ 负荷有影响。在这里，我们检测到了人扁桃体组织中的 Aβ 肽沉积以及在嗅裂中发现的类似于扁桃体结石的组织。有趣的是，我们首次证明了（）聚集在 Aβ 沉积物周围或嵌入 Aβ 沉积物中的存在。值得注意的是，我们表明，用 处理可上调人扁桃体类器官和脑类器官培养物中的 Aβ 蛋白负荷，表明 在 Aβ 蛋白聚集中的新作用。这些发现表明，Aβ 和致病性细菌的储库可能是人类扁桃体的一个潜在治疗靶点，支持通过去除病原体来治疗抗生素以预防 AD 发病机制中 Aβ 肽的沉积。
