Li Chen, Nitka Meaghan V, Gloer James B, Campbell Jinx, Shearer Carol A
Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
J Nat Prod. 2003 Oct;66(10):1302-6. doi: 10.1021/np030225y.
Eight new polyketide metabolites, annularins A-H (1-8), along with the known compound (-)-(S)-p-hydroxyphenyllactic acid, were isolated from the organic extracts of the freshwater fungus Annulatascus triseptatus. Compounds 1-6 are 3,4,5-trisubstituted alpha-pyrones, and the fused bicyclic pyrone-furanone system in annularin F (6) has not been reported previously among natural products. Compounds 7 and 8 are 3,4-disubstituted alpha,beta-unsaturated gamma-lactones. Annularins A (1), B (2), C (3), and F (6) exhibited antibacterial activity.
从淡水真菌三隔环纹菌的有机提取物中分离出8种新的聚酮类代谢产物，环纹菌素A-H（1-8），以及已知化合物（-）-（S）-对羟基苯乳酸。化合物1-6是3,4,5-三取代的α-吡喃酮，环纹菌素F（6）中稠合的双环吡喃酮-呋喃酮体系在天然产物中尚未见报道。化合物7和8是3,4-二取代的α,β-不饱和γ-内酯。环纹菌素A（1）、B（2）、C（3）和F（6）具有抗菌活性。
