从海洋来源的镰刀菌中分离并鉴定新镰孢吡喃酮，以及对镰孢吡喃酮和脱氧镰孢吡喃酮的结构修正。

Isolation and structure elucidation of neofusapyrone from a marine-derived Fusarium species, and structural revision of fusapyrone and deoxyfusapyrone.

作者信息

Hiramatsu Fuminori, Miyajima Takeshi, Murayama Tetsuya, Takahashi Koetsu, Koseki Takuya, Shiono Yoshihito

机构信息

Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan.

出版信息

J Antibiot (Tokyo). 2006 Nov;59(11):704-9. doi: 10.1038/ja.2006.94.

DOI:10.1038/ja.2006.94

PMID:17256469

Abstract

Three polyketides containing a pyrone ring, neofusapyrone, fusapyrone, and deoxyfusapyrone, were isolated from the marine-derived fungus Fusarium sp. FH-146. Their structures were determined by extensive ID- and 2D-NMR and MS spectral analyses. Fusapyrone and deoxyfusapyrone were originally reported as a-pyrone derivatives; however, the revised structures indicate that they are gamma-pyrone derivatives. These three compounds exhibited antimicrobial activities.

摘要

从海洋来源的镰刀菌属真菌Fusarium sp. FH-146中分离出三种含有吡喃环的聚酮化合物，即新镰孢吡喃酮、镰孢吡喃酮和脱氧镰孢吡喃酮。通过广泛的一维和二维核磁共振以及质谱光谱分析确定了它们的结构。镰孢吡喃酮和脱氧镰孢吡喃酮最初被报道为α-吡喃衍生物；然而，修订后的结构表明它们是γ-吡喃衍生物。这三种化合物均表现出抗菌活性。