Bobrovnik S A, Efetov K A, Petrova Iu I, Komisarenko S V
Palladin Institute of Biochemistry, National Academy of Sciencis, Kyiv, Ukraine.
Ukr Biokhim Zh (1999). 2003 May-Jun;75(3):104-8.
New data concerning biological properties of polyreactive immunoglobulins (PRIG) were obtained as a result of treatment of mouse serum immunoglobulins by 4 M KSCN and are presented in the paper. In particular, the capacity of PRIG to bind C1q, the subunit of the first component of complement was studied. It was shown that PRIG's binding capacity to C1q is similar to that of intact immunoglobulins. Intravenous administration of PRIG into mice together with either sheep red blood cells or heat-inactivated staphylococcal bacteria did not affect the immune response to these antigens. Meanwhile, the same administration of PRIG together with the purified protein derivate of tuberculin resulted in 10-fold increase of mouse antibody response to PPD. These results demonstrate that PRIG can have some immuno-modulating properties concerning low-immunogenic antigens.
通过用4M硫氰酸钾处理小鼠血清免疫球蛋白，获得了有关多反应性免疫球蛋白（PRIG）生物学特性的新数据，并在本文中予以呈现。特别地，研究了PRIG结合补体第一成分的亚基C1q的能力。结果表明，PRIG与C1q的结合能力与完整免疫球蛋白相似。将PRIG与绵羊红细胞或热灭活的葡萄球菌一起静脉注射到小鼠体内，并不影响对这些抗原的免疫反应。同时，将PRIG与结核菌素纯蛋白衍生物一起进行相同的注射，导致小鼠对PPD的抗体反应增加了10倍。这些结果表明，PRIG对于低免疫原性抗原可能具有一些免疫调节特性。
