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儿童胱氨酸尿石症的体外冲击波碎石术:疗效与并发症

Extracorporeal shock wave lithotripsy for cystine urolithiasis in children: outcome and complications.

作者信息

Slavković Andjelka, Radovanović Miladin, Sirić Zlatko, Vlajković Marina, Stefanović Vladisav

机构信息

Clinic for Pediatric Surgery, Clinical Center, Nis, Yugoslavia.

出版信息

Int Urol Nephrol. 2002;34(4):457-61. doi: 10.1023/a:1025694230131.

Abstract

The Siemens Lithostar Litotriptor was used to treat 6 children with cystine nephrolithiasis, previously treated by open surgery. Five children had renal calculi (3 multiple caliceal, 2 pelvis) and one had ureteral calculus. Stone size ranged from 0.2-2.5 cm in diameter, and stone burden was from 0.24 to 10.81 cm3 per kidney. From one to 4 ESWL sessions per unit were applied, with a total of 1,800 to 12,000 shock waves. The stone free rate at 3 months was 50%. A complete elimination was obtained with cystine stones in renal pelvis and ureter, however, up to 4 ESWL treatments failed in caliceal stones. Rather location of cystine calculi than previous surgery was associated with ESWL success rate. Two patients with positive urine cultures were successfully treated with appropriate antibiotics before ESWL was attempted. Perirenal hematoma was major complication demonstrated by radionuclide scintigraphy in one patient, and resolved spontaneously by 3 months. In the combined treatment of cystine urolithiasis in children ESWL, as auxillary procedure, was safe and effective in pelvis stone but failed in caliceal stones. Medical dissolution for retained fragments was found effective.

摘要

西门子Lithostar碎石机用于治疗6例曾接受开放手术治疗的胱氨酸肾结石患儿。5例患儿有肾结石(3例为多发肾盏结石,2例为肾盂结石),1例有输尿管结石。结石直径为0.2 - 2.5厘米,每侧肾脏的结石负荷为0.24至10.81立方厘米。每个单位应用1至4次体外冲击波碎石(ESWL)治疗,总共施加1800至12000次冲击波。3个月时的结石清除率为50%。肾盂和输尿管的胱氨酸结石可完全清除,但肾盏结石最多接受4次ESWL治疗仍失败。与ESWL成功率相关的是胱氨酸结石的位置而非既往手术史。2例尿培养阳性的患者在尝试ESWL之前用适当的抗生素成功治疗。放射性核素闪烁扫描显示1例患者出现主要并发症肾周血肿,3个月时自行消退。在儿童胱氨酸尿路结石的联合治疗中,ESWL作为辅助治疗方法,对肾盂结石安全有效,但对肾盏结石无效。发现药物溶解残留碎片有效。

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